NCT05899686

Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

Effect of Tetanic Stimuli on Photoplethysmogram During General Anesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

Detailed description

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Conditions

• Stress Reaction

Interventions

Type	Name	Description
DEVICE	Tetanic Stimulus	5 second 100 Hz 70 mA tetanic stimulus will be applied to three different anatomical locations in each subject.

Timeline

• Start date: 2016-01-27
• Primary completion: 2016-05-12
• Completion: 2016-05-12
• First posted: 2023-06-12
• Last updated: 2024-05-16
• Results posted: 2024-05-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study