NCT05898347

Nevoid Basal Cell Carcinomas in Gorlin Syndrome

Nevoid Basal Cell Carcinomas in Young People With Gorlin Syndrome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 6 Years – 17 Years
• Healthy volunteers: Not accepted

Summary

The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome. Clinical experience and some case-reports suggest that nevoid basal cell carcinomas have an indolent course with slow growth and that they can sometimes regress. However, no systematic research has previously been performed. Increased knowledge about nevoid basal cell carcinomas and the use of dermatoscopy could be of great clinical value in the follow-up and treatment of individuals with nevoid basal cell carcinoma syndrome.

Conditions

• Basal Cell Carcinoma
• Gorlin Syndrome

Interventions

Type	Name	Description
OTHER	Active surveillance	Skin lesions clinically compatible with nevoid basal cell carcinomas are documented with measurements, clinical description, clinical photos and dermatoscopy photos every eight months for two years. Three representative skin lesions are selected at the first visit to be removed by skin biopsy at the end of the observation period (two years) for histopathological analyses. If a nevoid basal cell carcinoma shows a certain increases in size (according to pre-specified criteria of the study protocol), ulcerates, gets unevenly demarcated or give functional complaints during the observation period, the skin lesion will be excised.

Timeline

• Start date: 2023-06-01
• Primary completion: 2025-06-01
• Completion: 2025-12-31
• First posted: 2023-06-12
• Last updated: 2023-06-12

Locations

1 site across 1 country: Norway