NCT05893966

Prospective Cohort for Tumor Bed Boost Radiotherapy in HER2 Positive Breast Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: Female
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to analyze treatment outcomes related to tumor bed boost of postoperative radiation therapy in patient with HER2+ breast cancer who underwent breast conserving surgery. The main questions it aims to answer are: * 7-year ipsilateral breast tumor recurrence * 7-year disease-free survival * 7-year locoregional recurrence * 7-year overall survival * Adverse events of radiation therapy Participants will be assessed by multi-dimensional methods after radiation therapy: * Assessment for the disease status (disease-free or recurrence) including physical and radiologic examination * Assessment for the adverse events according to CTCAE version 5.0

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	Whole breast irradiation +/- tumor bed boost	Postoperative whole breast irradiation (3D-conformal radiation therapy or IMRT) with or without tumor bed boost (sequential or simultaneous integrated boost)

Timeline

• Start date: 2022-11-29
• Primary completion: 2025-11-29
• Completion: 2032-11-29
• First posted: 2023-06-08
• Last updated: 2025-06-29

Locations

1 site across 1 country: South Korea