NCT05891938

Effects of Hydrogen Gas Inhalation on Adults of Various Ages

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Wonju Severance Christian Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages.

Detailed description

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants including those dropped out (5%) were screened and enrolled. The selected participants were treated as a single group without randomization. Evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. Furthermore, evaluation of dementia-related biomarkers such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6).

Conditions

• Alzheimer Disease

Interventions

Type	Name	Description
OTHER	H2 gas inhalation	H2 gas inhalation treatment for 4 weeks in on community dwelling adults of various ages

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-03-01
• Completion: 2023-04-05
• First posted: 2023-06-07
• Last updated: 2023-06-07

Locations

2 sites across 1 country: South Korea