NCT05890885

MS Fatigue and tDCS on Fatigue in Multiple Sclerosis

The Effect of Home-Based Transcranial Direct Current Stimulation on Fatigue in Multiple Sclerosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The available therapeutic strategies for Multiple Sclerosis (MS)-related symptoms are usually faced with limited efficacy and numerous side effects. Patients with MS frequently suffer from fatigue, affective symptoms, and cognitive deficits.

Detailed description

For these reasons, non-invasive brain stimulation (NIBS) techniques, namely transcranial direct current stimulation (tDCS) might be of help in this context. tDCS is a new NIBS technique with a good safety profile, easy implementation, good patients' tolerance and little or no adverse effects. tDCS uses low levels of constant current delivered to specific brain area via sponge electrodes placed on the scalp. tDCS modifies the polarization of the exposed neuronal circuits. Indeed, it modulates the spontaneous neuronal excitability and activity by a tonic depolarization or hyperpolarization of resting membrane potential. Therefore, applying a home-based intervention is of interest in a population suffering from high levels of physical disability prohibiting them from frequently coming to seek care at the hospital

Conditions

• Fatigue in Multiple Sclerosis

Interventions

Type	Name	Description
PROCEDURE	Real left prefrontal tDCS - sham	Real left prefrontal tDCS followed by sham tDCS after a 4-week washout period
PROCEDURE	Sham - Real left prefrontal tDCS	Sham tDCS followed by real left prefrontal tDCS after a 4-week washout period

Timeline

• Start date: 2022-09-01
• Primary completion: 2023-04-20
• Completion: 2023-04-20
• First posted: 2023-06-06
• Last updated: 2026-01-22

Locations

1 site across 1 country: France