NCT05887505

Effects of Vitamin D Status and Multiple Mega-dose Supplementation on Health Care Disparities in Perioperative Patients With Hepatocellular Carcinoma Receiving Hepatectomy

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Taoyuan General Hospital · Other Government
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

High concentrations of parathyroid hormone (PTH) are common in patients with hepatocellular carcinoma (HCC). This study is aimed to investigate effects of vitamin D status and its multiple mega-dosage supplementation on PTH and clinical outcomes in HCC patients before and after hepatectomy. It's a single-center, prospective, parallel, double-blind, placebo-controlled study for 120 eligible subjects. The subjects will receive consecutively 3-day intervention treatments from 7th day before surgery. 30-day postoperative mortality, postoperative complications, and laboratory data will be evaluated.

Conditions

• Hepatocellular Carcinoma
• Liver Function
• Postoperative Complications

Interventions

Type	Name	Description
OTHER	Vitamin D	Oral supplementation of 576,000IU/day vitamin D3 in 3 consecutive days
OTHER	Placebo	Oral supplementation of placebo in 3 consecutive days.

Timeline

• Start date: 2023-06-09
• Primary completion: 2027-12-01
• Completion: 2027-12-31
• First posted: 2023-06-02
• Last updated: 2023-06-06