NCT05887232

Comparison of Co2 Laser Versus Co2 Laser With PRP in Scars

Comparative Study on the Efficacy of Fractional CO2 and Fractional CO2 Laser With Autologous Platelet Rich Plasma in Scars

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Combined Military Hospital Abbottabad · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars. Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023. Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is \<25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is \>75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value \<0.05 as significant, was used.

Conditions

• CO2 Laser in Scars

Interventions

Type	Name	Description
PROCEDURE	Fractional CO2 laser	Patient in group A received FCL treatments four sessions with four weeks apart
PROCEDURE	Fractional CO2 with Platelet Rich Plasma	Group B received four PRP and FCL sessions 4 weeks apart

Timeline

• Start date: 2022-11-01
• Primary completion: 2023-04-30
• Completion: 2023-04-30
• First posted: 2023-06-02
• Last updated: 2023-06-02

Locations

1 site across 1 country: Pakistan