NCT05885269

Comparative Efficacy of Tacrolimus and Clobetasol Propionate in Alopecia Areata

Comparative Efficacy of Tacrolimus 0.1% and Clobetasol Propionate 0.05% in the Treatment of Alopecia Areata

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Combined Military Hospital Abbottabad · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Methodology: The 70 patients of age 20 to 50 years presented to the out-patient department of CMH Abbottabad suffering from alopecia areata were enrolled. The non-probability consecutive sampling technique was used. Patient in group-A applied clobetasol propionate 0.05% twice daily, whereas Group-B applied topical tacrolimus 0.1% twice daily for upto 3 months. The Patients were assessed at baseline, 4th weeks, 8th week and 12th week after treatment of each session. Hair loss was calculated from SALT score at presentation and on follow-up after 3 months. The degree of response was assessed on the basis of hair re-growth as excellent (\>75% re-growth), Marked (51-75% re-growth), moderate (26-50% re-growth), or slight (≤25% re-growth). To determine statistical significance χ2-square test, taking p-value \<0.05 as significant, was used.

Conditions

• Alopecia Areata

Interventions

Type	Name	Description
DRUG	Group A applied topical Clobetasol Propionate	Patient in group-A applied clobetasol propionate 0.05% twice daily for upto 03 months
DRUG	Group B applied topical Tacrolimus	Group-B applied topical tacrolimus 0.1% twice daily for upto 3 months.

Timeline

• Start date: 2022-11-01
• Primary completion: 2023-04-30
• Completion: 2023-04-30
• First posted: 2023-06-01
• Last updated: 2023-06-01

Locations

1 site across 1 country: Pakistan