NCT05884905

Safety of Short Hydration Method for Cisplatin Administration Compared With Conventional Hydration

Randomized Study Evaluating Safety of Short Hydration Method for Cisplatin Administration Compared With Conventional Hydration

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to evaluate safety of short hydration with cisplatin administration. The main outcome is renal dysfunction following cisplatin use with short hydration protocol. Another group of patients received conventional hydration is the historical control for comparison (Randomized phase II design with a reference standard treatment control arm)

Conditions

• Renal Insufficiency
• Cis-Platinum Nephropathy

Interventions

Type	Name	Description
PROCEDURE	short hydration	NSS infusion prior to and following cisplatin administration within 6 hours
PROCEDURE	conventional hydration	NSS infusion prior to and following cisplatin administration over 24 hours

Timeline

• Start date: 2023-03-07
• Primary completion: 2025-01-07
• Completion: 2025-03-07
• First posted: 2023-06-01
• Last updated: 2023-06-01

Locations

1 site across 1 country: Thailand