NCT05883891

Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 52 (actual)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Alcoholic hepatitis (AH) is the most severe form of acute alcohol-related liver disease. Maddrey's discriminant function (mDF) \>32 defines the severe form of AH, which is associated with a high mortality. Corticosteroid therapy (CS) represents the main medical treatment that may reduce short-term mortality. Lille score at day 7 assesses the therapeutic response to steroid therapy. At present, no parameters able to predict the response to steroid therapy have been highlighted. The mDF depends mainly on prothrombin time (PT). Aim of the present study was to evaluate if the PT value could predict the response to CS in severe AH (sAH).

Conditions

• Alcoholic Hepatitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	prothrombin time	Prothrombin time at value at diagnosis was used to assess the presence of a correlation with Lille score at day 7 and therefore wether it could predict response to medical treatment.

Timeline

• Start date: 2017-06-01
• Primary completion: 2022-09-30
• Completion: 2022-11-30
• First posted: 2023-06-01
• Last updated: 2023-06-01

Locations

1 site across 1 country: Italy