NCT05883345

Blood Tests for Gastritis and Gastric Neoplasms

Validation of Blood Test Finding for the Diagnosis of Gastritis and Gastric Neoplasms

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,490 (actual)
• Sponsor: Konkuk University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Helicobacter pylori infection rate is decreasing in younger population; however, biennial gastroscopy is still recommended for all Koreans aged between 40 and 75 years. This study aimed to validate blood tests for gastric cancer screening according to the infection status of H. pylori (naive, current, and past infection).

Detailed description

Helicobacter pylori-seropositive rates are decreasing in South Korea. Seroprevalence was 74.3% in 1990, but it decreased to 43.9% in 2016. In Koreans, most gastric cancers are related to H. pylori infection. H. pylori-negative gastric cancers were found only in 2.3% among the 1,833 Korean gastric cancer patients. Despite these facts, the national guideline still recommends biennial gastroscopy for all Koreans aged between 40 and 75 years. Therefore, 8,462,570 (63.1%) Koreans underwent gastric cancer screening among the target population of 13,404,927 individuals in 2021. In H. pylori-seroprevalent populations, diagnostic criteria for naive status should be strict based on histology, endoscopy, and serum pepsinogen (PG) assay findings. Naive condition should be diagnosed only when both invasive and non-invasive H. pylori tests show negative findings. Furthermore, there should be no intestinal metaplasia and atrophy on serum PG assay, endoscopy, and histology findings in H. pylori-naive participants. Based on those findings, H. pylori infection will be confirmed when invasive tests or urea breath test was positive. H. pylori-naive status will be diagnosed if there was no eradication history, no serologically detected atrophy (PG I ≤70 ng/mL and PG I/II ≤3), and no intestinal metaplasia or atrophy on endoscopy and histology. This study aimed to determine the validity of blood tests for gastric cancer screening according to the H. pylori infection status. We tried to identify significant variables using GastroPanel tests and traditional serum PG assays in patients with gastric neoplasms.

Conditions

• Cancer Screening Tests

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum blood test for Helicobacter pylori immunoglobulin G, pepsinogen, and gastrin-17 levels	Endoscopic biopsy

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-08-30
• Completion: 2024-08-30
• First posted: 2023-05-31
• Last updated: 2025-03-11
• Results posted: 2025-03-11

Locations

1 site across 1 country: South Korea