NCT05882006

Gallstones and Risk of Inflammatory Bowel Disease

A Multicenter Case-control Study of the Association Between the Presence of Gallstone Disease and Risk of Inflammatory Bowel Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,035 (actual)
• Sponsor: Hepatopancreatobiliary Surgery Institute of Gansu Province · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to evaluate the association between gallstone disease and the risk of inflammatory bowel disease.

Detailed description

Crohn's disease and ulcerative colitis , collectively known as inflammatory bowel diseases , have increased substantially over the past few decades affecting nearly 6.8 million individuals worldwide. The etiology of IBD remains obscure, possibly involving a complex interaction between the genetic, environmental or microbial factors and the immune responses. Gallstone disease is one of the most common and costly gastroenterological disorders, with a prevalence of 10-20% in Europe and America. Considering that gallstones and IBD also share specific risk factors, such as obesity, inappropriate diet and metabolic hormone levels, and have the pathophysiologic linkage, such as changes in gut microbiota composition and bile acid profile, the investigators propose that the occurrence of gallstones may predict the subsequence risk of IBD. However, investigations concerning the association is lacking.

Conditions

• Inflammatory Bowel Diseases

Interventions

Type	Name	Description
OTHER	gallstones	fellow up if the patients have gallstones

Timeline

• Start date: 2023-05-21
• Primary completion: 2024-11-16
• Completion: 2024-11-16
• First posted: 2023-05-31
• Last updated: 2024-11-19

Locations

4 sites across 1 country: China