NCT05880602

Nettle and Cranberry Capsules for Prevention of Urinary Tract Infection

Clinical Trial of Nettle and Cranberry Capsules for Prevention of Urinary Tract Infection

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Chung Shan Medical University · Academic / Other
• Sex: All
• Age: 30 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study investigates whether the oral intake of a nettle and cranberry complex capsule may prevent recurrent urinary tract infection (rUTI). Participants will be aged between 30 - 75 years of age, with confirmed diagnosis of UTI status. The participants will be assessed for several parameters and asked to take 2 nettle and cranberry complex capsules twice daily for 8 weeks. The parameters will include international prostate symptoms score (IPSS), overactive bladder symptom score (OABSS), international consultation on incontinence questionnaire - overactive bladder (ICIQ-OAB), 3-day bladder diary (3dBD), and urine routine.

Detailed description

Urinary tract infections (UTIs) are one of the most common bacterial infections affecting women. UTI occurs in 50-80% of women in the general population. About one in four women with one UTI episode will go on to develop frequent recurrences. Recurrent urinary tract infection (rUTI) is defined as repeated UTI with a frequency of at least two episodes in the preceding six months or three episodes in the past year. rUTI has been regarded as a substantial global healthcare problem. This investigation is a randomized, double-blind study. Subjects with confirmed diagnosis of rUTI are randomly assigned to control group or treatment group, and asked to orally intake 2 capsules of either placebo or nettle and cranberry complex capsules twice daily. Participants will be assessed for parameters, including international prostate symptoms score (IPSS) (male only), overactive bladder symptom score (OABSS), international consultation on incontinence questionnaire - overactive bladder (ICIQ-OAB), 3-day bladder diary (3dBD) and urine routine. The assessments are conducted at baseline, 4 weeks, and 8 weeks after the oral intake period. The parameters are used to compare and evaluate whether the nettle and cranberry complex capsule can prevention rUTI.

Conditions

• Urinary Tract Infection

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Nettle and Cranberry complex capsules	A specific capsule product, containing nettle and cranberry complex will be given to participants for oral intake for 8 weeks.
DIETARY_SUPPLEMENT	Placebo(starch)	A specific capsule product, containing starch will be given to participants for oral intake for 8 weeks.

Timeline

• Start date: 2023-07-05
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2023-05-30
• Last updated: 2025-09-26

Locations

1 site across 1 country: Taiwan