NCT05880485

Online Adaptive Radiotherapy Cervical Cancer With Reduced Margin for Cervical Cancer

A Prospective Study to Evaluate Online Adaptive Radiotherapy in Cervical Cancer With Reduced Margin

• Status: Active Not Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for cervical cancer. To explore the value of reduced margins in oART for cervical cancer, we conducted a prospective clinical trial to determine the clinical efficacy and toxicity of reduced margins.

Detailed description

This is an investigator-initiated efficacious, single-center, open-label clinical trial study. This study hypothesizes that the use of reduced PTV margins in oART for cervical cancer could decrease toxicity and achieve more accurate dosimetric coverage. A dose of 50.4 Gy is delivered to clinical target volume (CTV) with reduced margin oART. Patients receive cisplatin based concurrent chemotherapy. The primary endpoint is acute toxicity.

Conditions

• Uterine Cervical Neoplasm

Interventions

Type	Name	Description
RADIATION	online adaptive radiotherapy	PTV with 5-10 margins covers CTV

Timeline

• Start date: 2023-02-02
• Primary completion: 2023-11-06
• Completion: 2025-11-01
• First posted: 2023-05-30
• Last updated: 2024-11-25

Locations

1 site across 1 country: China