Trials / Not Yet Recruiting
Not Yet RecruitingNCT05880355
Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI
- Status
- Not Yet Recruiting
- Phase
- EARLY_Phase 1
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- Sponsor
- University of Virginia · Academic / Other
- Sex
- All
- Age
- 25 Years – 99 Years
- Healthy volunteers
- Not accepted
Summary
Subjects with urgently reperfused type I myocardial infarction (MI) will be recruited and randomized to receive either placebo or the oral inflammasome (NLRP3) inhibitor dapansutrile. The primarily outcome measure will be carotid plaque volume change over 6 months; secondary outcome measures will be plaque inflammatory activity and coronary microvascular function.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Dapansutrile | Oral inhibitor of NLRP3 |
| OTHER | Placebo | Non-active placebo |
Timeline
- Start date
- 2026-04-01
- Primary completion
- 2028-12-31
- Completion
- 2029-01-30
- First posted
- 2023-05-30
- Last updated
- 2025-06-04
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT05880355. Inclusion in this directory is not an endorsement.