NCT05877443

Barotrauma in Adults With Critical COVID-19

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 669 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19. If this is complications of the respiratory support used to treat patients hypoxemia or if it is a direct consequence of COVID-19 damaging the lung tissue is not known. The aim of this study is to investigate the incidence and type barotrauma, if there is an association between barotrauma and level of respiratory support used in the intensive care unit, and if barotrauma is associated with worse outcome compared to patients without barotrauma.

Conditions

• COVID-19
• Barotrauma

Interventions

Type	Name	Description
PROCEDURE	Open system	Oxygen delivered on open system, for example high flow nasal cannula or low flow oxygen by nasal cannula or face mask
PROCEDURE	Non-invasive mechanical ventilation	Respiratory support by for example continues or bilevel positive airway pressure
PROCEDURE	Invasive mechanical ventilation	Respiratory support delivered through endotracheal tube or tracheostomy

Timeline

• Start date: 2020-03-01
• Primary completion: 2021-05-31
• Completion: 2021-08-29
• First posted: 2023-05-26
• Last updated: 2023-05-30

Locations

1 site across 1 country: Sweden