NCT05874531

End-expiratory Occlusion Test and Prediction of Preload Dependence

End-expiratory Occlusion Test and Prediction of Preload Dependence: Echocardiographic and Hemodynamic Study in the ICU.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Mongi Slim Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Three sets of measurements of hemodynamic parameters and sub-aortic VTI were performed: before and at the end of 15 seconds end-expiratory occlusion and after 250 mL saline administration over 10 minutes. Patients were considered responders to fluid loading after an increase in sub-aortic VTI of more than 10% following a volume expansion. SPSS was used for statistic study. A p \< 0.05 was considered significant. The investigators performed univariate and then multivariate analysis.

Detailed description

The patients included were in the supine position in a prone position at 30°. They had continuous monitoring by: electrocardioscopy; pulse oximetry and invasive blood pressure. Diuresis was monitored hourly. A venous access to the superior vena cava territory (central venous catheter) was set up. The patients were sedated with a Ramsay score \> 4 and ventilated in controlled assisted mode. The sub-aortic TVI (in cm) was measured in an apical 5-chamber section by pulsed Doppler using a 1-5 MHz ultrasound probe (M-Turbo sonosite). Three sets of measurements of hemodynamic parameters and sub-aortic VTI were performed: before and at the end of 15 seconds end-expiratory occlusion and after 250 mL saline administration over 10 minutes. At each point, the investigators noted the hemodynamic, ultrasound and biological parameters.

Conditions

• Intensive Care Units
• Ultrasonography
• Blood Volume

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	End-expiratory occlusion test	15 seconds end-expiratory occlusion

Timeline

• Start date: 2023-05-15
• Primary completion: 2023-08-15
• Completion: 2023-09-15
• First posted: 2023-05-25
• Last updated: 2023-09-25

Locations

1 site across 1 country: Tunisia