NCT05874141

Comorbidities in Type 2 Diabetes Mellitus

Comorbidities in Type 2 Diabetes Mellitus: An Observational Study in Kharga City, New Valley Governate, Egypt

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 288 (estimated)
• Sponsor: New Valley University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Type 2 diabetes mellitus (DM) has adopted a top priority as it is a disease with an increasing prevalence. The number of people living with DM has increased more than fourfold over the past 40 years to more than 460 million people today

Detailed description

All-cause mortality rates have declined substantially in several high-income countries, including England. A diversification in non-fatal conditions in people with DM has also been reported. This is attributable to broader, non-vascular conditions. Due to increasing longevity among people with type 2 DM with increasing and diversifying multimorbidity in them, the health needs of people with Type 2 DM are therefore likely to be broad, and complex. Finding multimorbidity (two or more chronic conditions) is common in people with Type 2 DM and increasing, but the comorbidity profiles of people with T2DM vary substantially. Many studies have primarily focused on identifying multimorbidity patterns in the general population. The understanding of multimorbidity patterns and composition of specific comorbidities in people with DM, and how this varies across patient groups and during the course of the disease, is limited. Further knowledge of this could provide insight into providing more holistic and more personal approaches to clinical guideline development, care pathways, and secondary prevention.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	HBA1C	blood sample on EDTA
DIAGNOSTIC_TEST	Lipid profile, including total, LDL, and HDL cholesterol and Triglycerides	serum sample
DIAGNOSTIC_TEST	Urine analysis and urinary albumin-to-creatinine ratio	Morning urine sample
DIAGNOSTIC_TEST	Serum creatinine and estimated glomerular filtration rate	serum sample
DIAGNOSTIC_TEST	Complete blood count	blood sample on EDTA
DIAGNOSTIC_TEST	Thyroid-stimulating hormone	serum sample
DIAGNOSTIC_TEST	Serum iron, TIBC, Transferrin saturation and serum ferritin if needed	serum sample
PROCEDURE	Electrocardiography (ECG)	by electrocardiogram
PROCEDURE	Transthoracic echocardiography, Neck ultrasonography if needed and abdominopelvic ultrasound	imaging
PROCEDURE	Arterial duplex ultrasound of both lower limbs	imaging
DIAGNOSTIC_TEST	Random blood glucose	serum sample
DIAGNOSTIC_TEST	AST, ALT, albumin	serum sample

Timeline

• Start date: 2023-11-15
• Primary completion: 2025-12-30
• Completion: 2026-08-30
• First posted: 2023-05-24
• Last updated: 2025-08-14

Locations

1 site across 1 country: Egypt