NCT05872009

Gestational Diabetes Mellitus: "Placental-maternal Crosstalk and Future Health"

The GaP Study: Gestational Diabetes Mellitus: "Placental-maternal Crosstalk and Future Health

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 350 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: —

Summary

The GaP study is designed to close important knowledge gaps by: 1. exploring placental health and cellular ageing in GDM and the association with neonatal outcome 2. evaluating the effectiveness of current and novel maternal health follow-up strategies after GDM

Detailed description

The incidence of gestational diabetes mellitus (GDM) is increasing. GDM has potential adverse short and long term health effects for both the women and her offspring, and involves dysfunctional interaction between placenta and the maternal body. The burden for the individual, the health system and society warrants further investigations into the placental-maternal crosstalk in GDM in order to improve personalized pregnancy surveillance and follow-up. In Oslo county, nearly twice as many women who give birth suffer from GDM (5.7%) than from preeclampsia (2.3%). The large obstetric department at Ullevål provides an optimal environment for novel translational studies and clinical practical aspects of GDM. The GaP study is designed to close important knowledge gaps by: 1. exploring placental health and cellular ageing in GDM and the association with neonatal outcome 2. evaluating the effectiveness of current and novel maternal health follow-up strategies after GDM

Conditions

• Gestational Diabetes
• Cardiovascular Diseases
• Placenta Diseases

Timeline

• Start date: 2023-06-01
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2023-05-23
• Last updated: 2023-05-23

Locations

1 site across 1 country: Norway