NCT05868824

Dynamic Blood Inflammatory Profile in Atopic Dermatitis Patients (ADAMUNE)

Dynamic Blood Inflammatory Profile in Atopic Dermatitis Patients

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, single-center, class 2 study to better characterize the immune response in immune response in the blood of atopic dermatitis. Investigators are following in the referral center of Nice, 100 patients with atopic dermatitis. Investigators plan to include 30 patients. Blood samples will be collected to assess cytokine levels after non-specific immune stimulation. immune stimulation. Whole blood will be collected and stimulated with immune ligands (anti-CD3 T-cell stimulating ligands associated with Thymic Stromal LymphoPoietin (TSLP) or TLR agonist R848 7/8 agonist stimulating NK (natural killer) lymphocytes and promoting T cell response) on lyophilized freeze-dried spheres (LyoSphere, Qiagen) within 8 hours of blood collection.

Conditions

• Atopic Dermatitis

Interventions

Type	Name	Description
OTHER	Blood sample	A blood sample for assessing cytokines will be performed at baseline and at follow-up visit 3 months after initiation of treatment. The blood sample will be performed as part of blood tests done for standard AD follow up.

Timeline

• Start date: 2023-06-01
• Primary completion: 2026-02-03
• Completion: 2027-03-01
• First posted: 2023-05-22
• Last updated: 2026-03-18

Locations

1 site across 1 country: France