NCT05867784

Effect of Vitamin D Supplementation on the Efficacy of Ustekinumab in the Treatment of Crohn's Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Second Affiliated Hospital of Wenzhou Medical University · Academic / Other
• Sex: All
• Age: 15 Years – 65 Years
• Healthy volunteers: —

Summary

It is uncertain whether vitD3 supplementation is beneficial for the remission of Crohn's disease (CD). The effects of vitD3 supplements on the efficacy of ustekinumab in Chinese CD patients were retrospectively analyzed. Methods: Patients with moderate to severe CD were recorded. These patients were initially treated with UST. VitD3 supplementation was defined as 400IU/d vitD3 supplementation during the first infusion of UST and continued throughout the follow-up period. Disease activity was assessed using Harvey Bradshaw Index.

Conditions

• Ustekinumab
• Vitamin D Supplementation
• Crohn's Disease
• Clinical Efficacy

Timeline

• Start date: 2021-04-30
• Primary completion: 2022-02-15
• Completion: 2023-03-15
• First posted: 2023-05-22
• Last updated: 2023-05-22

Locations

1 site across 1 country: China