NCT05866302

Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients

Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients. A Multi-center, Observational Trial.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 375 (estimated)
• Sponsor: University of Michigan Rogel Cancer Center · Academic / Other
• Sex: All
• Age: 36 Months
• Healthy volunteers: —

Summary

The study will have two separate patient cohorts: Cohort 1 will include patients with newly diagnosed chronic graft versus host disease (GVHD), whereas cohort 2 will include patients with newly diagnosed chronic lung disease (CLD). For cohort 1, the primary objective will be to characterize PRM metrics at the onset of chronic GVHD and determine if a PRM signature is present that will predict 1-year CLD free survival. For cohort 2, the primary objective will focus on characterizing PRM at the onset of CLD and determine if PRM can predict the trajectory in lung function decline in affected patients.

Conditions

• Chronic Lung Disease
• Hematopoietic Cell Transplantation
• Graft Versus Host Disease

Timeline

• Start date: 2023-05-30
• Primary completion: 2028-05-01
• Completion: 2028-05-01
• First posted: 2023-05-19
• Last updated: 2025-10-20

Locations

6 sites across 1 country: United States