NCT05866250

Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery

Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery From Acute Kidney Injury in Critically Ill Patients: a Prospective Observational Multicenter Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 467 (actual)
• Sponsor: The First Hospital of Jilin University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to observe the correlation between dynamic changes in the Doppler-based renal resistive index (RI) and the occurrence of persistent acute kidney injury (AKI) in critically ill patients. The main questions it aims to answer are: * Are dynamic changes of RI within 24 or 48 hours associated with the prognosis of AKI (NO AKI, transient AKI, persistent AKI)? * what are the influencing factors of changes in RI? Participants will measure values of RI in patients at admission (0 hour), after 24 hours and after 48 hours, respectively, and collect characters such as age, sex, vital signs, Apache II, diagnosis, renal function, applied drugs, fluid, 72-hour renal function and renal replacement, followed renal replacement and the mortality rate at 28 days.

Detailed description

NO AKI is defined as No AKI occurred within 72 hour after ICU admission; Transient AKI is defined as AKI with recovery, which refers to the reduction in AKI stage ( (i.e., a decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy) occurring with 72 hour after ICU admission; Persistent AKI is defined as AKI without recovery occurring with 72 hour after ICU admission.

Conditions

• Acute Kidney Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Doppler-based renal resistive index	The kidney's interlobular or arcuate artery was preferentially selected and measured by pulse-wave Doppler.

Timeline

• Start date: 2023-08-01
• Primary completion: 2023-12-30
• Completion: 2024-03-01
• First posted: 2023-05-19
• Last updated: 2024-05-16

Locations

7 sites across 1 country: China