NCT05861791

Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty

Comparison of Patient-controlled Analgesia With Background Opioid Versus Non-opioid Infusion for Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: a Randomized, Non-inferiority Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 98 (actual)
• Sponsor: Chung-Ang University Gwangmyeong Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

Patients who undergoing total knee arthroplasty under spinal analgesia will be recruited and randomly assigned to the following two groups according to the regimen of PCA: (A) opioid group who receive only fentanyl citrate 1200mcg for continuous infusion drug, (B) non-opioid group who receive ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug. All the patients will receive additional fentanyl citrate as bolus injection drug if they need more analgesics postoperatively.

Conditions

• Postoperative Pain, Acute

Interventions

Type	Name	Description
DRUG	Fentanyl	opioid group receives only fentanyl citrate 1200mcg for continuous infusion drug
DRUG	ketorolac tromethamine with nefopam hydrochloride	non-opioid group receives ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug

Timeline

• Start date: 2023-02-07
• Primary completion: 2024-07-12
• Completion: 2024-07-12
• First posted: 2023-05-17
• Last updated: 2024-07-15

Locations

1 site across 1 country: South Korea