NCT05861700

The Effect of Bicarbonate Profiling in Dialysis Fluid on Phosphate Removal During Hemodialysis and Blood pH

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Medical University of Warsaw · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hyperphosphatemia is still an unresolved problem among hemodialysis patients and significantly increases the risk of death from cardiovascular diseases. Research to date has not answered the question of whether dialysate bicarbonate concentration profiling can improve phosphate removal and its concentration without negative impact on the acid-base balance. This study addressed this issue. Twenty stable hemodialysis patients will enroll to a four-week study during which different dialysate bicarbonate concentration profiles will be used each week. Each patient will undergo the following profiles (one-week periods): Treatment A - stable dialysate bicarbonate concentration Dbic 35 mmol/L during the whole HD session, Treatment B - Dbic 35 mmol/L for the first two hours and Dbic 30 mmol/L for the next two hours and Treatment C - the opposite mid-HD change Dbic from 30 to 35 mmol/L and one week wash-out period between Treatment B and C. We will collect blood samples each hour during the session and one hour after HD completion.

Conditions

• Phosphorus Metabolism Disorders
• Acid-Base Balance Disorder

Interventions

Type	Name	Description
OTHER	Group 1: B) Dbic 35 -30 mmol/L C) Dbic 30- 35 mmol/L	A change Dbic in a middle of hemodialysis
OTHER	Group 2: C) Dbic 30 -35 mmol/L B) Dbic 35- 30 mmol/L	A change Dbic in a middle of hemodialysis

Timeline

• Start date: 2018-05-21
• Primary completion: 2020-12-31
• Completion: 2022-08-31
• First posted: 2023-05-17
• Last updated: 2023-05-23

Locations

1 site across 1 country: Poland