NCT05861076

Moringa Powder Acceptability Trial Among Healthy Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University of California, Berkeley · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The study is a randomized acceptability trial involving the provision of three different doses of Moringa powder to be consumed daily by study participants.

Detailed description

Moringa is a drought-resistant nutrient-dense tree with high concentrations of anti-inflammatory plant chemicals in its edible leaves and seeds. In preclinical studies Moringa has been shown to improve insulin resistance, dyslipidemia, and high blood pressure. But its effects in humans remain unclear. Moringa (20g leaf powder on two different days) supplementation decreased post-prandial glucose in Saharawi refugees with type 2 diabetes, compared to controls (Leone, et. al., 2018). In a randomized control trial in Spain, Moringa consumed as six daily capsules of dry leaf powder (2.4 g/day) for 12 weeks, significant decreased fasting blood glucose and glycated hemoglobin (HbA1c) among prediabetic subjects (Gomez-Martinez, et. al., 2021). The investigators are conducting a testing trial of Moringa oleifera leaves, offered as powder, to be added to foods and/or drinks to test safety, acceptability and consumption of it in three different doses: 1 tsp, 2 tsp, and 3 tsp. Study participants will be randomly allocated to one of the three doses. Among the studies that have been conducted with human subjects (individuals with diabetes), no adverse effects have been reported with whole leaf powder at up to a single dose of 50 g or using 8 g per day dose for 40 days (Stohs \& Hartman, 2015). The outcomes to be measured in this testing trial are the following: * Consumption (measured by self-report and skin carotenoid level, as a biomarker of consumption of fruits and vegetables) * Acceptability (measured by rating the taste of the moringa powder when consumed with foods/drinks) * Safety (measured by self-report of any potential side effects, such as digestive issues due to fiber content) Results from this trial will suggest an acceptable dose in a population not yet diagnosed with a specific disease (e.g. diabetes) and therefore potentially less willing to consume it in doses that could make taste a potential barrier for consumption.

Conditions

• Consumption
• Acceptability
• Side Effect

Interventions

Type	Name	Description
OTHER	Moringa Powder - Low Dose	1 teaspoon Moringa leaf powder to be consumed with usual food and/or drinks daily for 7 days
OTHER	Moringa Powder - Medium Dose	2 teaspoons Moringa leaf powder to be consumed with usual food and/or drinks daily for 7 days
OTHER	Moringa Powder - High Dose	3 teaspoons Moringa leaf powder to be consumed with usual food and/or drinks daily for 7 days

Timeline

• Start date: 2023-01-03
• Primary completion: 2023-05-11
• Completion: 2023-05-30
• First posted: 2023-05-16
• Last updated: 2025-01-01

Locations

1 site across 1 country: United States