NCT05854589

Effect of Topical Application of Hypertonic Saline on Melanoma on Its Sizes and Number.

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Rafik Batroussy · Academic / Other
• Sex: All
• Age: 5 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effectiveness of applying Hypertonic Saline solution directly on the Melanomas in reducing their sizes and/or number.

Detailed description

Many previous studies have shown that Cancer cells are over-hydrated, and that Hyponatraemia exists in many cases of Cancer. The Cancer cell's viability depends on Angiogenesis and formation of blood vessels that carry water and nutrients to the rapidly-dividing Cancer cells. This study tests the hypothesis that reducing the water content of Melanoma could lead to increasing its tonicity and hence inhibiting its growth. This reduction of water content can be achieved using Osmotic Pressure differential via applying highly saline solution - made by Sodium Chloride crystals wet with water - directly on the Melanoma for a certain amount of time, thus leading to water withdrawal from Melanoma cells. While the surrounding healthy skin cells can sustain temporary dehydration, Melanoma cells could be negatively affected.

Conditions

• Melanoma (Skin)

Interventions

Type	Name	Description
DRUG	Sodium Chloride Granules	Sodium Chloride crystals
OTHER	Water	Plain distilled water

Timeline

• Start date: 2023-08-01
• Primary completion: 2024-02-29
• Completion: 2024-06-30
• First posted: 2023-05-11
• Last updated: 2023-05-11