NCT05850598

Effect of rTMS of the Cerebellum on Parkinson's Disease

Effect of Low-frequency rTMS of the Cerebellum on Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Jiangsu Province Nanjing Brain Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn about the efficacy of low-frequency rTMS of the cerebellum in Parkinson's disease.

Detailed description

The main question it aims to answer is: how to improve Parkinson's disease by rTMS. Participants will be treated with active low-frequency rTMS/sham rTMS over the cerebellum and receive: 1) resting state functional magnetic resonance imaging (fMRI), 2) blood sampling, and 3) Unified Parkinson Disease Rating Scale (UPDRS) before and after the treatment course. Researchers will compare the data collected from fMRI scan, blood sample analysis, and UPDRS rating between the active rTMS group and sham controls before and after the treatment to see if there are meliorating effects of rTMS on Parkinson's disease.

Conditions

• Parkinson Disease
• Transcranial Magnetic Stimulation

Interventions

Type	Name	Description
DEVICE	sham rTMS	The coil was held while disconnected from the stimulator, and rTMS noise was presented with computer loudspeakers with recorded sound from a real stimulation (20 minutes for each side of the lateral cerebellum everyday for 2 weeks).
DEVICE	active rTMS	Low-frequency (1 Hz) rTMS at with a stimulation intensity of 95% of the motor threshold will be delivered over the bilateral cerebellum for patients with Parkinson's disease (20 minutes for each side of the lateral cerebellum everyday for 2 weeks).

Timeline

• Start date: 2023-05-10
• Primary completion: 2025-10-21
• Completion: 2025-11-21
• First posted: 2023-05-09
• Last updated: 2025-11-24

Locations

1 site across 1 country: China