NCT05847933

Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance

A Pilot Study on the Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 105 (actual)
• Sponsor: Prof. Dominique de Quervain, MD · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

A pilot study, examining the effect of repeated transcranial magnetic brain stimulation (rTMS) on the formation of memories with negative valence. The investigators hypothesize that an effective rTMS protocol to reduce memory performance for adverse events can be found.

Conditions

• Memory, Episodic

Interventions

Type	Name	Description
DEVICE	rTMS (cTBS 50Hz experiment)	rTMS using cTBS protocol with the following characteristics: * Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band) * Intensity: 80% of resting motor threshold (rMT) * Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0) * Duration: 40 seconds for each hemisphere, 80 seconds in total. * Timing: Immediately before viewing pictures in pictorial memory task (off-line)
DEVICE	rTMS (cTBS sham)	rTMS using cTBS protocol with the following characteristics: * Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band) * Intensity: 0% * Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0) * Duration: 40 seconds for each hemisphere, 80 seconds in total. * Timing: Immediately before viewing pictures in pictorial memory task (off-line)
DEVICE	rTMS (cTBS 50 Hz active control)	rTMS using cTBS protocol with the following characteristics: * Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band) * Intensity: 80% of resting motor threshold (rMT) * Location: Right superior frontal cortex * Duration: 40 seconds for each hemisphere, 80 seconds in total. * Timing: Immediately before viewing pictures in pictorial memory task (off-line)
DEVICE	rTMS (high frequency)	rTMS using high frequency protocol with the following characteristics: * Frequency: 20 Hz * Intensity: 120% of rMT for rMT \< 54% \& 65% of MSO for rMT ≥ 54% * Location: temporo-occipital cortex of the dominant brain hemisphere * Duration: 20 minutes, continuously * Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
DEVICE	rTMS (low frequency)	rTMS using Low frequency protocol with the following characteristics: * Frequency: 1 Hz * Intensity: 110% of rMT * Location: temporo-occipital cortex of dominant brain hemisphere (MNI left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0) * Duration: 30 minutes, continuously * Timing: Starting 10 minutes before and continuing during the picture viewing and valence rating of the pictures of the memory task (on-line).
DEVICE	rTMS (high frequency sham)	* Frequency: 20 Hz * Intensity: 10% of MSO * Location: temporo-occipital cortex of the dominant brain hemisphere * Duration: 20 minutes, continuously * Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
DEVICE	rTMS (high frequency active control)	* Frequency: 20 Hz * Intensity: 120% of rMT for rMT \< 54% \& 65% of MSO for rMT ≥ 54% * Location: right superior frontal cortex of the dominant brain hemisphere * Duration: 20 minutes, continuously * Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
DEVICE	rTMS (low frequency active control )	* Frequency: 1 Hz * Intensity: 110% of rMT * Location: Right superior frontal cortex of the dominant brain hemisphere * Duration: 6 minutes * Timing: Starting 1 minutes before and continuing during the memory task (Online)
DEVICE	rTMS ( cTBS 30 Hz active control)	* Bilateral continuous theta burst stimulation (cTBS) 30 Hz: * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on right superior frontal cortex * Duration: 33.3 seconds for each side * Timing: Immediately before pictorial memory task (off-line)
DEVICE	rTMS (cTBS 30 Hz)	* Bilateral continuous theta burst stimulation (cTBS) 30 Hz: * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on left and right temporo-occipital cortex * Duration: 33.3 seconds for each side * Timing: Immediately before pictorial memory task (off-line)

Timeline

• Start date: 2023-06-06
• Primary completion: 2025-04-01
• Completion: 2025-05-31
• First posted: 2023-05-08
• Last updated: 2025-07-29

Locations

1 site across 1 country: Switzerland