NCT05842343

Food Intake and IgA Microbiota in Anorexia Nervosa

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Anorexia nervosa is characterized by intestinal dysbiosis, related to the feeding behavior impairment presented by these patients. Pathophysiologic hypotheses are involving the trouble of the microbiota-gut-brain axis in the field of mental diseases.

Detailed description

Anorexia nervosa is characterized by intestinal dysbiosis, related to the feeding behavior impairment presented by these patients. Here we aim to characterize the IgA-coated fraction of bacteria from the intestinal microbiota, linked to the regulation of the mucosal immune system and the epithelium physiology. Abnormalities of this microbiota are reported in inflammatory bowel disease and are associated to immune trouble. As food intake plays a key role in shaping microbiota, we aim to correlate data from IgA microbiota to food intake specificity, and to anorexia nervosa phenotypes.

Conditions

• Anorexia Nervosa
• Healthy Volunteer

Interventions

Type	Name	Description
OTHER	Stool sample	Purification by affinity of the IgA coated bacteria from a fecal solution. Genomic analysis of the bacteria for diversity and richness
OTHER	Food intake evaluation	Measure (by survey) of food group intake for : lipids /proteins / fibers / carbohydrates

Timeline

• Start date: 2023-10-13
• Primary completion: 2023-11-28
• Completion: 2024-02-02
• First posted: 2023-05-06
• Last updated: 2025-11-26

Locations

1 site across 1 country: France