NCT05841069

Short and Prolonged Conservative Treatment in Patients With Adhesive Intestinal Obstruction

Multicenter Controlled Randomized Prospective Study of the Comparative Efficacy of Early and Delayed Surgical Interventions in Patients With Acute Adhesive Intestinal Obstruction

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: North-Western State Medical University named after I.I.Mechnikov · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will compare the results of 24 h conservative treatment and N h conservative treatment of adhesive small bowel obstruction (where N = 72 h minus duration of intestinal obstruction).

Detailed description

Patients with acute adhesive intestinal obstruction, who dont need an emergency operation, will be given water insoluble contrast per os and randomized into two groups - early and delayed surgery. The first group will receive conservative treatment within no more than 24 h. Duration of non-operative treatment in second group will be 72 h minus duration of intestinal obstruction, based on the onset of symptoms. In both groups surgery will be performed if contrast will not reach colon in mentioned terms or clinical deterioration signs will appear. The results of 24 h conservative treatment and N h conservative treatment (where N = 72 h minus duration of intestinal obstruction) will be compared.

Conditions

• Small Bowel Obstruction
• Small Bowel Adhesion

Interventions

Type	Name	Description
PROCEDURE	Adhesiolysis	Median laparotomy with subsequent detection of intestinal obstruction cause and adhesiolysis.
RADIATION	X-ray examination	Plain X-ray of abdomen (1-4 times) with water insoluble contrast.
PROCEDURE	Conservative treatment	A set of measures aimed at non-operative resolution of acute intestinal obstruction - nasogastric tube, infusion therapy.

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-12-31
• Completion: 2024-02-01
• First posted: 2023-05-03
• Last updated: 2023-05-03

Locations

4 sites across 1 country: Russia