NCT05839821

Rhythmic Auditory Stimulation on Neural Activity During Finger-tapping in PD Patients

Effects and Neural Mechanisms of Rhythmic Auditory Stimulation on Upper-limb Movements in Patients With Parkinson's Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 72 (estimated)
• Sponsor: The Hong Kong Polytechnic University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. The investigators will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine real-time neural activity when patients with PD and healthy controls listen to RAS and execute finger-tapping task simultaneously. Methods and analysis This study will recruit patients with PD and healthy controls. Electroencephalography (EEG) will be used under six conditions related to a finger-tapping task. Two-way repeated measures analysis of variance will be performed to investigate the group and condition effects on neural mechanisms. Study significance This study will offer evidence on RAS effects and mechanisms by investigating the changes in upper-limb movements and neural mechanisms during auditory-motor entrainment. Results from this study will provide a solid foundation for further research and clinical applications of RAS.

Conditions

• Acoustic Stimulation
• Parkinson Disease
• Electroencephalography

Interventions

Type	Name	Description
BEHAVIORAL	noF-noRAS	resting state, that is, without finger-tapping and without listening to RAS
BEHAVIORAL	F-noRAS	finger-tapping without listening to RAS
BEHAVIORAL	noF-100RAS	listening to RAS with the 100% of the baseline tempo and without finger-tapping
BEHAVIORAL	F-100RAS	finger-tapping and listening to RAS with 100 % of baseline tempo
BEHAVIORAL	F-105RAS	finger-tapping and listening to RAS with 105 % of baseline tempo
BEHAVIORAL	F-110RAS	finger-tapping and listening to RAS with 110 % of baseline tempo

Timeline

• Start date: 2023-06-01
• Primary completion: 2026-03-31
• Completion: 2026-03-31
• First posted: 2023-05-03
• Last updated: 2023-05-03