NCT05838183

Interstitial Lung Disease and Obstructive Sleep Apnea

Study on the Clinical Characteristics of Interstitial Lung Disease and Obstructive Sleep Apnea

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: Dan Liu · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Clinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with the metagenomic next generation sequencing(mNGS) results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease. All patients undergo polysomnography (PSG) and drug-induced sleep endoscopy(DISE). The biological specimens was obtained for molecular biology or other tests.We detected ZNF331, Claudin1, Claudin2, Claudin3, Claudin4, and IL22 as biomarkers to differentiate the diagnostic efficiency of OSA in ILD, ILD+OSA, OSA, and Ctrl groups, respectively

Conditions

• ILD OSA

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	The relationship between imaging and ROSE and NGS	The correlation between ROSE and NGS in imaging and bronchoscopy of ILD patients was observed

Timeline

• Start date: 2019-09-01
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2023-05-01
• Last updated: 2026-02-10

Locations

1 site across 1 country: China