NCT05837936

Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

A Prospective Observational Study Evaluating Extubation Criteria in Children Less 10 Years of Age and Younger Undergoing Intravenous Anesthesia

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 600 (estimated)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 9 Years
• Healthy volunteers: Not accepted

Summary

Because Propofol is the primary "anesthetic agent," and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous anesthesia (TIVA) it is likely that different criteria may be predictive of extubation success in these patients compared to inhalational anesthesia.

Detailed description

This is because these anesthetic regimens have different pharmacologic mechanisms of actions, and therefore interact with central nervous system in different ways leading to potentially the need for different extubation criteria in patients receiving TIVA or SIIVA. Additionally, intravenous agents likely have less of an effect on airway reflexes and ventilation at light levels of anesthesia. This study is proposing an observational study to examine the predictive value of various extubation criteria in the setting of SIIVA and TIVA.

Conditions

• Extubation

Interventions

Type	Name	Description
OTHER	Total intravenous anesthesia (TIVA)	TIVA anesthetic -no inhalational gases for surgery
OTHER	Sevoflurane initiated intravenous anesthesia (SIIVA)	SIIVA - sevoflurane anesthetic gases for surgery

Timeline

• Start date: 2023-03-28
• Primary completion: 2028-03-01
• Completion: 2028-03-01
• First posted: 2023-05-01
• Last updated: 2025-12-18

Locations

2 sites across 2 countries: United States, Australia