NCT05837858

The Human Metabolic Profile and Gut Microbiota Under Various Dietary Quality

Study on Biomarkers of Whole Grain Dietary Intake in Chinese Population

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Peking University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this food intervention study is to screen/validate the whole grain food intake biomarker in health Chinese's population.

Detailed description

Although increased consumption of whole grains (WGs) is associated with improved health outcomes, the dietary intake assessment and health mechanisms for WGs or WG-containing food remain unresolved. In addition, information regarding its consumption and health effects in Chinese people is scarce. Biomarkers of WGs intake would allow a more accurate assessment of its consumption in nutrition studies. The investigators want to perform a crossover study where participants were subjected to a WG-wheat flour or a refine wheat-flour Chinese diet. Using a metabolomics approach, the investigators aimed to identify the WG-specific metabolites present in plasma/urine after consumption WG or WG foods, including new candidate biomarkers of WG intake.

Conditions

• Biomarkers

Interventions

Type	Name	Description
OTHER	whole grain-wheat flour food+standardized meals	whole grain food made by 50 g whole grain wheat flour
OTHER	refined wheat flour food+standardized meals	refined grain food made by 50 g refined wheat flour

Timeline

• Start date: 2023-04-28
• Primary completion: 2023-05-24
• Completion: 2023-05-24
• First posted: 2023-05-01
• Last updated: 2023-08-03

Locations

1 site across 1 country: China