NCT05837403

The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 460 (actual)
• Sponsor: Al-Kindy College of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain. injection of platelet rich plasma under fissure base and edges had the advantage of improved fissure healing and reduction of the pain, with minimal side effects.

Detailed description

Thirty milliliters of venous blood were withdrawn into eight syringes with preloaded 0.4 milliliters of anticoagulant (dextrose solution A) in each syringe to achieve concentration of 9:1. The mixture centrifuged for 3000 round per minute for three minutes. After centrifugation separation of supernatant from the red blood cells, using three way-stopcock connector to collect the supernatant of all syringes into four new syringes that preloaded with 1 microgram of Prostaglandin E1 that diluted in normal saline (0.05 milliliters). The four syringes centrifuge at 4000 round per minute for 15 minutes. The supernatant discarded using a three way-stopcock connector. The sediment mixed with vortex mixer (Vortex V-1 plus, BIOSAN).

Conditions

• Fissure in Ano

Interventions

Type	Name	Description
PROCEDURE	Platelet rich plasma injection	venous blood drown from the patient, centrifugation and separation of platelet rich plasma, injection under fissure and edges base.
DRUG	Nitroglycerin ointment	application of the ointment twice daily

Timeline

• Start date: 2020-10-01
• Primary completion: 2022-07-30
• Completion: 2022-09-30
• First posted: 2023-05-01
• Last updated: 2023-05-03

Locations

1 site across 1 country: Iraq