NCT05833477

Tracing Changed Production of Red Blood Cells

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In competitive sport, it is illegal to manipulate erythropoiesis. Manipulated erythropoiesis can indirectly be identified by atypical fluctuations in key haematological variables. However, this method also has limitations and as it is known that some athletes still manipulate erythropoiesis it is necessary to develop new and more sensitive detection methods. The primary purpose of the study is to examine the importance of altered erythropoiesis for surface and intracellular erythrocyte proteins, the number of immature reticulocytes, and for the haematological characteristics of the erythrocyte, such as volume, haemoglobin concentration and concentration of glycosylated haemoglobin, to assess whether these can be used to identify changed erythropoiesis. Furthermore, the aim is to examine whether these parameters are affected by freezer storage of erythrocytes.

Conditions

• Erythrocytosis
• Erythropoiesis Abnormal

Interventions

Type	Name	Description
DRUG	Recombinant human erythropoietin	Recombinant human erythropoietin treatment three times per week for three weeks

Timeline

• Start date: 2022-10-28
• Primary completion: 2022-12-16
• Completion: 2022-12-16
• First posted: 2023-04-27
• Last updated: 2023-04-27

Locations

1 site across 1 country: Denmark