NCT05831709

The Influence of Hormone Replacement Therapy and Supervised Exercise Training on Body Composition, Cardiovascular Risk and Insulin Sensitivity in Postmenopausal Women

De Invloed Van Hormoonsubstitutietherapie en Gesuperviseerde Training op Lichaamssamenstelling, Cardiovasculair Risico en Insulinegevoeligheid Bij Postmenopauzale Vrouwen

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 390 (estimated)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: Female
• Age: 45 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This trial investigates whether supervised training in combination with hormonal substitution therapy has an impact on body composition, cardiovascular risk, risk for dementia, osteoporosis and insulin sensitivity in postmenopausal women.

Detailed description

270 postmenopausal women will be included. Each woman will perform a 12 to 24 weeks sports program with supervised training exercises.

Conditions

• Postmenopause
• Menopausal Complaints

Interventions

Type	Name	Description
OTHER	Exercise program	The intervention consists of a supervised exercise program
DRUG	Hormonal substitution therapy per SOC	Subjects take hormonal substitution therapy per standard of care

Timeline

• Start date: 2023-05-12
• Primary completion: 2027-12-31
• Completion: 2028-12-01
• First posted: 2023-04-26
• Last updated: 2025-11-18

Locations

1 site across 1 country: Belgium