NCT05830747

Effect of Pre-emptive Dose of Prednisone Versus Placebo in Impacted Third Molar Surgery

Three-dimensional Facial Swelling Evaluation of Pre-operative Single-dose of Prednisone in Third Molar Surgery: a Split-mouth Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: University Magna Graecia · Academic / Other
• Sex: All
• Age: 18 Years – 32 Years
• Healthy volunteers: Accepted

Summary

The present study proposes to compare the effect of a single preoperative dose of prednisone versus placebo in terms of facial swelling, trismus and pain after surgical removal of the mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Detailed description

This study aims to compare the effect of a single preoperative dose of prednisone versus placebo in terms of facial swelling, trismus, and pain after surgical removal of M3M in a split-mouth randomized controlled clinical trial. Facial swelling will be evaluated using an innovative three-dimensional digital technique.

Conditions

• Facial Swelling
• Tooth Position Anomalies
• Tooth, Impacted
• Tooth Extraction Status Nos
• Tooth Avulsion

Interventions

Type	Name	Description
DRUG	Prednisone	Pre-operative drug administration before third molar surgery
DRUG	Placebo	Pre-operative Placebo administration before third molar surgery

Timeline

• Start date: 2022-02-01
• Primary completion: 2022-10-25
• Completion: 2022-12-10
• First posted: 2023-04-26
• Last updated: 2023-04-26

Locations

1 site across 1 country: Italy