NCT05830617

Modulation of Cortical Gamma Synchrony in Stroke

Assessment and Modulation of Cortical Gamma Synchrony to Predict and Improve Stroke Recovery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 220 (estimated)
• Sponsor: IRCCS San Camillo, Venezia, Italy · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

In the last decades, the research in neuroimaging-informed stroke prognosis and treatment has had a little clinical impact, often because of the costs of bringing complex procedures to the bedside. Cerebral stroke remains the leading cause of disability, with 65% of survivors chronically impaired at 6 months. Gamma synchrony (GS) is a fundamental mechanism of cortical function and can be estimated and modulated in a simple, inexpensive, and reliable way. It has provided valuable and cost-effective guidance in several neuropsychiatric conditions. In previous studies, we developed simple yet robust methods for assessing and manipulating GS and proved its relationship with clinical impairment in preliminary data. The aim of the present project is to predict and improve stroke recovery by leveraging cortical mapping and modulation of GS via transcranial alternating current stimulation (tACS), a safe and inexpensive technique. The project capitalizes on technology readily available to the Italian national health system.

Detailed description

The project will consist of 3 Work Packages (WPs): * The aim of WP1 is to map the relationship between GS and clinical outcomes with EEG. * The aim of WP2 is to translate GS assessment and modulation to bedside. * The aim of WP3 is to modulate GS to improve rehabilitation outcomes.

Conditions

• Stroke

Interventions

Type	Name	Description
DEVICE	real tACS	The effect of transcranial alternating current stimulation (tACS) will be investigated in WP3. Patients will undergo standard intensive rehabilitation plus gamma tACS for two weeks.
DEVICE	sham tACS	In WP3, patients will undergo standard intensive rehabilitation plus sham tACS for two weeks.

Timeline

• Start date: 2021-03-23
• Primary completion: 2024-03-23
• Completion: 2024-03-23
• First posted: 2023-04-26
• Last updated: 2023-04-26

Locations

1 site across 1 country: Italy