NCT05830032

Impact of Dietary Fibre Consumption on Digestive Comfort

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of Glasgow · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this randomised, placebo-controlled, cross-over study is to compare the impact different fibres have on gastrointestinal symptoms when they are consumed individually or as mixtures in healthy adults. The impact of different fibres on the experience of symptoms and stool parameters will be assessed.

Detailed description

Global sugar consumption is higher than recommended and there are suggestions that this may be linked to the development of non-communicable diseases including dental caries, and obesity. There are many alternatives to sugars that can be used in foods including certain dietary fibres such as inulin or fructo-oligosaccharides. Most dietary fibres can be fully or partially fermented in the colon by the commensal microbiota, producing beneficial bioactive molecules. However, the rapid production of gas during the fermentation of highly soluble fermentable fibres may cause undesirable symptoms for some people. Dietary exposure to the fibres used in food reformulation, including inulin and soluble corn fibre, is increasing and the impact this may have on gastrointestinal symptoms is unclear. The impact of fibres with different physicochemical characteristics and fermentabilities may differ when consumed in mixtures compared to individually. The aim of this study is to investigate the impact different fibres have on gastrointestinal symptoms when they are consumed individually or as mixtures and how this relates to the composition of the stool.

Conditions

• Gastrointestinal Discomfort

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Soluble corn fibre	As a powdered beverage
DIETARY_SUPPLEMENT	Inulin	As a powdered beverage
DIETARY_SUPPLEMENT	soluble corn fibre and inulin	As a powdered beverage
DIETARY_SUPPLEMENT	Maltodextrin	As a powdered beverage

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-05-20
• Completion: 2023-10-25
• First posted: 2023-04-26
• Last updated: 2023-04-26

Locations

1 site across 1 country: United Kingdom