NCT05828446

Improving Hepatocellular Carcinoma Screening

Prospective Comparison of Diagnostic Performance and Cost-effectiveness of US and Abbreviated MRI for Hepatocellular Carcinoma Screening

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 330 (estimated)
• Sponsor: Naik Vietti Violi · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a monocentric, single blind, interventional, single arm study. It is designed to compare the rates of detection of hepatocellular carcinoma (HCC) by ultrasound (US) used in clinical routine vs. abbreviated magnetic resonance imaging (AMRI). The hypothesis is that dynamic AMRI with extracellular contrast agent injection has a higher patient-level detection rate of HCC than screening US and non-contrast AMRI. Interested and eligible patients will be enrolled and undergo HCC screening rounds including US +/- contrast-enhanced US (clinical routine) and screening MRI within the same week bi-annually.

Conditions

• Magnetic Resonance Imaging
• Hepatocellular Carcinoma
• Screening
• Contrast-enhanced US

Interventions

Type	Name	Description
DEVICE	MRI	To compare the diagnostic performance of US+/- Constrast-enhanced US and AMRI for HCC detection in an at-risk population

Timeline

• Start date: 2023-04-01
• Primary completion: 2026-04-30
• Completion: 2027-04-30
• First posted: 2023-04-25
• Last updated: 2025-04-03

Locations

1 site across 1 country: Switzerland