NCT05827484

The Effect of Combined Use of Anti-fibrotic Agent With Platelet Rich Plasma on Skeletal Muscle Healing After Acute Injuries

A New Treatment Modality For Skeletal Muscles Sports Injuries; Losartan Combination With PRP

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Mostafa Hassanein, Msc · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The aim of this comparative study is to determine whether or not LOSARTAN with its anti-fibrotic action has an added effect when administrated with platelet rich plasma injection on skeletal muscle healing and on decreasing the fibrous scar after muscle injuries in comparison with the sole administration of platelet rich plasma.

Conditions

• PRP
• Losartan
• Muscle Injury
• Sport Injury

Interventions

Type	Name	Description
BIOLOGICAL	Autologous platelets rich plasma	30 ml of venous blood were drawn from the participant by means of venipuncture. The collected blood was mixed with 3 ml anti-coagulant acid citrate dextrose in the centrifugation sterile tube. The blood sample was then centrifuged using the centrifugation machine. 3 ml of PRP from the buffy coat layer were loaded in a 5 ml syringe. After local sterilization and draping of the site of injection and under US guidance the hematoma was aspirated from the injury site and the freshly prepared PRP was injected.
COMBINATION_PRODUCT	Autologous platelets rich plasma + oral LOSARTAN administration	in addition to local PRP injection, 50 mg / day of LOSARTAN (Cozaar® 50 mg film-coated tablets) were administrated to the study group orally every morning from day 5 and till day 30 after injury.

Timeline

• Start date: 2016-10-10
• Primary completion: 2017-09-05
• Completion: 2017-12-12
• First posted: 2023-04-25
• Last updated: 2023-07-14