NCT05827211

The Usefulness of Antibiotics in Smokers Receiving Dental Implants

Asepsis During Periodontal Surgery Involving Oral Implants and the Usefulness of Antibiotics: a Prospective, Randomized, Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Arab American University (Palestine) · Academic / Other
• Sex: All
• Age: 19 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Objectives: This randomized clinical trial will compare the usefulness of pre- and postoperative antibiotics while strict asepsis will be followed during periodontal surgery in smokers diagnosed with Stage III Grade C Generalized Periodontitis. Material and Methods: Two groups of 40 consecutive patients each with fully or partially edentulous jaws will be enrolled. Antibiotics group (GrAB+): will receive oral doxycycline 200 mg, 1 h pre-operatively and 100 mg g for 9 days post-operatively. Non-antibiotics group (GrAB- ): will receive a placebo (no antibiotics). Bacterial samples will be taken from the peri-oral skin before and at the end of the surgery. In 12 patients in each group, samples will also be taken from the nares. A visual analogue scale will evaluate symptoms of infection/ inflammation by both the patient and the periodontist at suture removal.

Conditions

• Dental Implant Therapy

Interventions

Type	Name	Description
PROCEDURE	Antibiotic group	Partially or fully edentulous smoker patients will be treated by dental implants and will receive systemic antibiotics
PROCEDURE	Non-Antibiotic group	Partially or fully edentulous smoker patients will be treated by dental implants and will receive placebo

Timeline

• Start date: 2023-04-02
• Primary completion: 2023-04-30
• Completion: 2023-06-10
• First posted: 2023-04-24
• Last updated: 2023-07-20

Locations

1 site across 1 country: Palestinian Territories