NCT05826717

Effect of Matrices on Serum Fructose.

Effects of the Food Matrix on Serum Fructose Peaks

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Epidemiological evidence is accumulating that a high consumption of added sugars is associated with metabolic diseases such as non-alcoholic fatty liver disease and type 2 diabetes. Fructose, one of the principal added sugars, is believed to be the most disadvantageous sugar. Data from a large population-based cohort demonstrated that fructose intake from fruit juice and sugar-sweetened beverages, but not whole fruits, is associated with higher intrahepatic lipid content. A study in mice demonstrated that fast fructose exposure resulted in higher intrahepatic lipid content than slow fructose exposure. The food matrix, i.e. the complex spatial organisation of and interactions between nutrients, may account for the fast versus slow fructose exposure and subsequent health consequences. Therefore the investigators aim to investigate the role of the fructose matrices on serum fructose peaks. The investigators hypothesize that liquid fructose matrices will cause higher serum fructose peaks in comparison to solid fructose matrices. Objective: To quantify serum fructose peaks within 150 minutes following intake of fructose-containing matrices.

Conditions

• Fructose Metabolism Disorder

Interventions

Type	Name	Description
OTHER	Apple	20g fructose in \[x\] g of apple
OTHER	Mashed apple	20g fructose in \[x\] g of mashed apple
OTHER	Apple juice	20g fructose in \[x\] ml apple juice
OTHER	Fructose powder in water	20g fructose in \[x\] ml water

Timeline

• Start date: 2022-12-15
• Primary completion: 2024-12-20
• Completion: 2024-12-20
• First posted: 2023-04-24
• Last updated: 2025-02-20

Locations

1 site across 1 country: Netherlands