Trials / Recruiting
RecruitingNCT05826444
Microvascular Cardiac Allograft Vasculopathy Trial
Morphological and Functional Phenotype of Isolated Microvascular Cardiac Allograft Vasculopathy in Heart Transplant Recipients
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- German Heart Institute · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The aim of the mCAV study is a comprehensive characterization of the genetic, morphological and functional phenotype of isolated microvascular graft vasculopathy (mCAV) after orthotopic heart transplantation (OHT). The utilized methods include dynamic echocardiography, magnetic resonance imaging, invasive microvascular resistance measurements, histology, cellular calcium-signaling and magnetocardiography as well as molecular genetic expression analysis (miRNA based).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Echocardiography | Echocardiography with afterload change |
| DIAGNOSTIC_TEST | Magnetic resonance imaging | Stress-MRI |
| DIAGNOSTIC_TEST | Magnetocardiography | Magnetocardiography |
| DIAGNOSTIC_TEST | Histology | Histological analysis |
| DIAGNOSTIC_TEST | Genetics | miRNA sequencing |
| DIAGNOSTIC_TEST | calcium signaling | cardiomyocyte calcium signaling |
| DIAGNOSTIC_TEST | IMR | Index of microvascular resistance measurement |
| DIAGNOSTIC_TEST | Angio-IMR | Angiography derived post-processing index if microvascular resistance |
Timeline
- Start date
- 2022-10-01
- Primary completion
- 2025-12-31
- Completion
- 2025-12-31
- First posted
- 2023-04-24
- Last updated
- 2024-08-12
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT05826444. Inclusion in this directory is not an endorsement.