NCT05824520

Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy

Coronary Computed Tomography-Derived Fraction Flow Reserve (FFR)-Guided Invasive Treatment Strategy (ITS) Versus Optimal Medical Therapy (OMT) Alone in Patient With Chronic Coronary Syndrome

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,066 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The overall purpose of ACCURATE II trial is to compare the clinical outcomes of CT-derived FFR guided strategy versus medical therapy in patients with chronic coronary syndrome.

Detailed description

ACCURATE II is a prospective, multicenter, randomized clinical trial comparing the clinical outcome and cost-effectiveness of the two management strategies. CT-FFR-guided invasive treatment strategy versus optimal medical therapy, in management of patients with chronic coronary syndrome. The study is powered to detect if the primary endpoint by the CT-FFR-guided strategy is superior to the medical therapy strategy.

Conditions

• Coronary Artery Disease
• Myocardial Ischaemia

Interventions

Type	Name	Description
OTHER	ITS plus OMT	Invasive treatment strategy plus optimal medical therapy
OTHER	OMT	Optimal medical therapy alone

Timeline

• Start date: 2024-10-10
• Primary completion: 2028-10-20
• Completion: 2032-10-20
• First posted: 2023-04-21
• Last updated: 2026-02-02

Locations

1 site across 1 country: China