NCT05823389

Flapless Emdogain in the Treatment of Periodontal Residual Pockets

The Use of Flapless Enamel Matrix Derivative in Treating Periodontal Residual Pockets: A Single-centre Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Arab American University (Palestine) · Academic / Other
• Sex: All
• Age: 19 Years – 75 Years
• Healthy volunteers: Accepted

Summary

48 adult patients participated in a single-centre randomized clinical trial with split- mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for generalized periodontitis with at least 2 teeth with residual probing pocket depths (PPD) ≥5 and ≤8 mm, with bleeding on probing (BOP). Two teeth with similar PPD were randomized to receive re-instrumentation either with (test) or without (control) adjunctive flapless administration of EMD. Differences in the changes of PPD and BOP from baseline to 6 and 12 months will be analysed, and the frequencies of pocket closure (PPD ≤4 mm and no BOP) will be compared

Conditions

• Chronic Periodontitis, Generalized

Interventions

Type	Name	Description
PROCEDURE	Re-instrumentation with flapless Emdogain application	Teeth with deep probing pocket depths were randomized to receive re-instrumentation with adjunctive flapless administration of EMD
PROCEDURE	Re-instrumentation with placebo application	Teeth with deep probing pocket depths were randomized to receive re-instrumentation with adjunctive placebo application

Timeline

• Start date: 2019-09-02
• Primary completion: 2022-10-01
• Completion: 2022-12-15
• First posted: 2023-04-21
• Last updated: 2023-04-21

Locations

1 site across 1 country: Palestinian Territories