NCT05821816

Effect of Transcranial Direct Current Stimulation (tDCS) on Post-stroke Patients on Neuromotor Recovery

Evaluation of the Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neurodegeneration and Neuromotor Recovery on Post-stroke Patients. a Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: I.R.C.C.S. Fondazione Santa Lucia · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to evaluate whether a non-invasive brain stimulation technique (Transcranial Direct Current Stimulation) can influence the secondary neurodegeneration observed after a stroke (assessed based on serum concentration of neurofilaments) and can improve the functional outcome.

Detailed description

The present preliminary study aims to evaluate the effects of tDCS (transcranial direct current stimulation) on functional recovery in subacute stroke patients and on neurodegeneration, measuring Neurofilament light chain (NfL) in blood. It will evaluate: * baseline NfL levels in patients with subacute stroke; * the correlation between motor recovery and the blood concentration of NfL in subjects treated with tDCS compared to the control group. * the effect of tDCS on motor recovery and NfL levels in the 3 months after the stroke event;

Conditions

• Stroke

Interventions

Type	Name	Description
DEVICE	tDCS	Use of Transcranial direct current stimulation for 20 minutes per day, 5 days a week, at 2mA
OTHER	Conventional rehabilitative treatment	Physiotherapy treatment consisting in two treatments per day of 40 minutes each

Timeline

• Start date: 2023-03-02
• Primary completion: 2025-02-01
• Completion: 2025-02-01
• First posted: 2023-04-20
• Last updated: 2025-03-13

Locations

1 site across 1 country: Italy