NCT05821634

Personalizing Treatment Delivery

Digital Phenotyping of Anxiety and Anxiety-Related Alcohol Comorbidity and Treatment

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 81 (estimated)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society. The proposed research will use digital technology to examine person-specific risk factors predicting problematic alcohol use in individuals vulnerable to anxiety and anxiety-related disorders and will use this information to design a personalized intervention for individuals seeking psychological treatment. Results from this research will integrate output from novel and innovative digital technology methods into psychotherapy, advancing research on personalized treatment and prevention efforts.

Conditions

• Anxiety Disorders and Symptoms
• PTSD and Trauma-related Symptoms
• Alcohol; Use, Problem; Alcohol Use Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Personalized intervention condition: Cognitive behavioral therapy skills	An 11-session cognitive behavioral therapy (CBT) skills based intervention will be delivered to participants randomized to the personalized intervention. Influential constructs will be identified using the person specific digital phenotyping model, targeted using CBT skills, and tracked across sessions.
BEHAVIORAL	Therapeutic control condition: Cognitive behavioral therapy skills	Participants randomized to this condition will receive an 11-session CBT skills based treatment targeting a non-personalized construct selected from the person-specific digital phenotyping model.
BEHAVIORAL	Tracking control condition: Supportive counseling	Participants randomized to this condition will receive 11 supportive counseling sessions that are non-directive in nature (providing support and validation for non-acute weekly stressors). Participants will continue digital phenotyping, controlling for the effect of counseling and digital phenotyping.

Timeline

• Start date: 2024-10-21
• Primary completion: 2026-05-01
• Completion: 2027-04-01
• First posted: 2023-04-20
• Last updated: 2025-05-29

Locations

1 site across 1 country: United States